JPH0363018B2 - - Google Patents
Info
- Publication number
- JPH0363018B2 JPH0363018B2 JP57173226A JP17322682A JPH0363018B2 JP H0363018 B2 JPH0363018 B2 JP H0363018B2 JP 57173226 A JP57173226 A JP 57173226A JP 17322682 A JP17322682 A JP 17322682A JP H0363018 B2 JPH0363018 B2 JP H0363018B2
- Authority
- JP
- Japan
- Prior art keywords
- membrane
- urease
- immobilized
- urea
- electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012528 membrane Substances 0.000 claims description 46
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 29
- 239000004202 carbamide Substances 0.000 claims description 29
- 125000003277 amino group Chemical group 0.000 claims description 18
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 13
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 10
- 108010046334 Urease Proteins 0.000 claims description 10
- 239000007864 aqueous solution Substances 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 108010039918 Polylysine Proteins 0.000 claims description 6
- -1 ammonium ions Chemical class 0.000 claims description 6
- 229920000656 polylysine Polymers 0.000 claims description 6
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 4
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 3
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims description 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 description 11
- 102000004190 Enzymes Human genes 0.000 description 11
- 239000000523 sample Substances 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 230000010220 ion permeability Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000007853 buffer solution Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 2
- GTKRFUAGOKINCA-UHFFFAOYSA-M chlorosilver;silver Chemical compound [Ag].[Ag]Cl GTKRFUAGOKINCA-UHFFFAOYSA-M 0.000 description 2
- 239000008151 electrolyte solution Substances 0.000 description 2
- 229940021013 electrolyte solution Drugs 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/817—Enzyme or microbe electrode
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57173226A JPS5963554A (ja) | 1982-10-04 | 1982-10-04 | ウレア−ゼ固定化尿素電極およびその製造方法 |
| US06/537,511 US4476005A (en) | 1982-10-04 | 1983-09-30 | Urease-immobilized urea electrode and process for preparing the same |
| DE3335691A DE3335691C2 (de) | 1982-10-04 | 1983-09-30 | Harnstoffelektrode mit einer immobilisierte Urease enthaltenden Membran und Verfahren zu ihrer Herstellung |
| CH5375/83A CH662890A5 (de) | 1982-10-04 | 1983-10-03 | Harnstoffelektrode mit einer immobilisierte urease enthaltenden membran und verfahren zur herstellung der membran. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57173226A JPS5963554A (ja) | 1982-10-04 | 1982-10-04 | ウレア−ゼ固定化尿素電極およびその製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5963554A JPS5963554A (ja) | 1984-04-11 |
| JPH0363018B2 true JPH0363018B2 (en]) | 1991-09-27 |
Family
ID=15956475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57173226A Granted JPS5963554A (ja) | 1982-10-04 | 1982-10-04 | ウレア−ゼ固定化尿素電極およびその製造方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4476005A (en]) |
| JP (1) | JPS5963554A (en]) |
| CH (1) | CH662890A5 (en]) |
| DE (1) | DE3335691C2 (en]) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3129988A1 (de) * | 1981-07-29 | 1983-02-17 | Siemens AG, 1000 Berlin und 8000 München | "verfahren und vorrichtung zur bestimmung von harnstoff" |
| JPS60100757A (ja) * | 1983-11-08 | 1985-06-04 | Hitachi Ltd | 酵素電極 |
| DD221368A1 (de) * | 1983-12-22 | 1985-04-24 | Messgeraetewerk Zwonitz Veb K | Vorrichtung zur automatischen effektivitaetsbestimmung bei der haemodialyse |
| AT384677B (de) * | 1985-04-16 | 1987-12-28 | Avl Verbrennungskraft Messtech | Sensor zur bestimmung von elektrolytkonzentrationen |
| US4894339A (en) * | 1985-12-18 | 1990-01-16 | Seitaikinouriyou Kagakuhin Sinseizogijutsu Kenkyu Kumiai | Immobilized enzyme membrane for a semiconductor sensor |
| US4829003A (en) * | 1986-08-28 | 1989-05-09 | Arney Jr Lawrence H | Pyroelectric enzyme detector |
| JPS63182559A (ja) * | 1987-01-24 | 1988-07-27 | Kanzaki Paper Mfg Co Ltd | 酵素電極の製造方法 |
| US5001048A (en) * | 1987-06-05 | 1991-03-19 | Aurthur D. Little, Inc. | Electrical biosensor containing a biological receptor immobilized and stabilized in a protein film |
| US5158868A (en) * | 1987-07-17 | 1992-10-27 | Iniziative Marittime 1991, S.R.L. | Method of sample analysis |
| US4997627A (en) * | 1987-07-17 | 1991-03-05 | Fisher Scientific Company | Sample analysis |
| DE3812442A1 (de) * | 1988-04-14 | 1989-10-26 | Fraunhofer Ges Forschung | Einrichtung zur enzympraeparation |
| US4973394A (en) * | 1988-09-02 | 1990-11-27 | Sri International | Immobilized valinomycin molecule for K+ sensor |
| US5264106A (en) * | 1988-10-07 | 1993-11-23 | Medisense, Inc. | Enhanced amperometric sensor |
| EP0368474B1 (en) * | 1988-10-07 | 1995-12-13 | MediSense, Inc. | Enhanced amperometric sensor |
| JPH073321Y2 (ja) * | 1988-12-10 | 1995-01-30 | 株式会社堀場製作所 | 流通型過酸化水素電極 |
| US5133937A (en) * | 1989-06-01 | 1992-07-28 | Iniziative Marittime, 1991 S.R.L. | Analysis system having a removable reaction cartridge and temperature control |
| JP2669497B2 (ja) * | 1994-12-26 | 1997-10-27 | 工業技術院長 | 酵素電極及びその製造方法 |
| US7153286B2 (en) | 2002-05-24 | 2006-12-26 | Baxter International Inc. | Automated dialysis system |
| US7175606B2 (en) | 2002-05-24 | 2007-02-13 | Baxter International Inc. | Disposable medical fluid unit having rigid frame |
| US7238164B2 (en) | 2002-07-19 | 2007-07-03 | Baxter International Inc. | Systems, methods and apparatuses for pumping cassette-based therapies |
| US8029454B2 (en) | 2003-11-05 | 2011-10-04 | Baxter International Inc. | High convection home hemodialysis/hemofiltration and sorbent system |
| US8617366B2 (en) * | 2005-12-12 | 2013-12-31 | Nova Biomedical Corporation | Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device |
| US9514283B2 (en) | 2008-07-09 | 2016-12-06 | Baxter International Inc. | Dialysis system having inventory management including online dextrose mixing |
| US8062513B2 (en) | 2008-07-09 | 2011-11-22 | Baxter International Inc. | Dialysis system and machine having therapy prescription recall |
| US10000784B2 (en) * | 2014-09-08 | 2018-06-19 | Siemens Healthcare Diagnostics Inc. | Creatinine biosensor and method of using the same |
| JP6952796B2 (ja) * | 2017-05-04 | 2021-10-20 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． | 溶解度を低下させた酵素で生産されるバイオセンサ、その生産方法及び使用方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3776819A (en) * | 1969-12-22 | 1973-12-04 | Monsanto Co | Urea determination and electrode therefor |
-
1982
- 1982-10-04 JP JP57173226A patent/JPS5963554A/ja active Granted
-
1983
- 1983-09-30 DE DE3335691A patent/DE3335691C2/de not_active Expired
- 1983-09-30 US US06/537,511 patent/US4476005A/en not_active Expired - Fee Related
- 1983-10-03 CH CH5375/83A patent/CH662890A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CH662890A5 (de) | 1987-10-30 |
| US4476005A (en) | 1984-10-09 |
| DE3335691A1 (de) | 1984-04-12 |
| DE3335691C2 (de) | 1987-03-26 |
| JPS5963554A (ja) | 1984-04-11 |
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